Time to Re-Evaluate Clozapine Practices

Although there have not been any studies directly examining the rates and predictors of symptomatic non-remission or treatment resistance in patients with FEP in an Asian population, it is reasonable to deduce, based on current literature, that reducing DUP and achieving early symptomatic response are perhaps the most crucial modifiable factors in preventing treatment resistance and improving long term outcomes. Hence, it will be wise for early intervention programmes to dedicate time and resources to examining and implementing strategies to not only reducing DUP, but also to achieving early symptomatic response.